Several placebo controlled studies show 92% of patients with onychomycosis see marked improvement in nail appearance within 8 weeks and 77% at 2 weeks respectively, when treated with a formulation containing these cosmetic agents. The cosmetic ingredients found in Tolcylen™ (including urea, lactic acid and propylene glycol) have been clinically shown to improve nail appearance of fungal and non-fungal nails beginning as early as 10 days. Within this category undecylenic acid has the lowest molecular weight by a significant margin. In a Cochrane database summary of 72 placebo controlled studies, undecylenic acid was the most effective topical drug for curing tinea pedis at 72%, while terbinafine was second at 70%, followed by tolnaftate at 64% and all azoles at 47%. Our proprietary formulation utilizes undecylenic acid as a cleansing and emulsifying excipient able to lower the surface tension of the other agents it is emulsified with in solution. Undecylenic acid is commonly utilized as an anti-fungal agent proven to kill fungal infections. Tolcylen™ Solution features emulsified tolnaftate in a solution form, providing both curative and preventive treatment to infection sites of the skin, including the cuticle, hyponychial and nail fold areas. While inexpensive to use and easy to mix, these seed oils are high surface tension, high molecular weight excipients which have been shown to actually block absorption of anti-fungal agents. As a comparison, most OTC topical antifungal products sold through physicians in the past utilize multiple seed oils as base excipients. Tolcylen™ Solution is the only OTC product utilizing an alcohol excipient formulation similar to topical prescription products which have been scientifically proven and FDA approved to penetrate and carry anti-fungal agents through the nail plate. Tolcylen™ Solution is a first product of any kind that can deliver a low molecular weight, low surface tension anti-fungal formulation to infection sites while also introducing cosmetic agents clinically proven to rapidly improve the appearance of thickened, dehydrated and discolored nails. Marlinz Pharma has multiple patents pending on the specialized processes and formulations required to create a product capable of changing the paradigm for treating fungal and non-fungal skin and nail disease symptoms. ![]() ![]() After 3 years of research and testing by leading pharmacological scientist, it was launched in early 2017 as an OTC physician only dispensed product. The Tolcylen™ Antifungal/Nail Renewal Solution was developed initially to be marketed as a prescription drug. Marlinz Pharma provides physicians with a new, powerful, office dispensed weapon capable of introducing a patent pending combination of FDA approved antifungal and multiple cosmetic agents to the site of fungal infections.
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